Histoid leprosy is a skin condition, a rare form of multibacillary leprosy See also[edit]. Leprosy · Skin lesion. References[edit]. ^ James, William D.; Berger. Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone. Summary Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate.

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Journal of Cutaneous Pathology. This page was last edited on 9 Julyat To receive news and publication updates for Case Reports in Pathology, enter your email address in the box below. View at Google Scholar G.

De-novo Histoid Leprosy

We report the case that occurred de novo in an elderly who presented with small to large lesions all lfprosy the body. Support Center Support Center. These bacilli were longer than the normal bacilli, scattered singly as well as arranged in clusters. Actinomycetaceae Actinomyces israelii Actinomycosis Cutaneous actinomycosis Tropheryma whipplei Whipple’s disease Arcanobacterium haemolyticum Arcanobacterium haemolyticum infection Actinomyces gerencseriae.

The bacilli appeared longer with tapering ends, when compared to ordinary lepra bacilli, usually arranged parallel histlid the long axis of cells. Histoid leprosy is an uncommon entity with specific clinical, histopathological and bacteriological features. A final diagnosis of de novo histoid leprosy was made. The histoid variety of lepromatous leprosy.

The nodules were distributed on his low back, buttocks, arms, and abdomen. No history of epistaxis and pedal edema. The third pattern is most commonly observed. The dermis revealed a lepeosy, circumscribed collection of benign spindle cells resembling fibroblasts, arranged in a whorled and storiform pattern, with entrapped but preserved small dermal nerve and adenexal structures.


It usually occurs in lepromatous patients, after dapsone monotherapy or rarely as de novo.

Histoid leprosy in North India. The reports leprody usually the size of 1. The patient responded well to the treatment. Sehgal VN, Srivastava G.

Case Reports in Pathology

FNAC is a simple cost-effective method of investigation that is more useful in tuberculoid, lepromatous, and histoid leprosy patients. There is a male preponderance, and the average age lprosy diagnosis is between 21 and 40 years.

A year-old man, an agriculturist by occupation, complained of multiple nodules all over the body, associated with itching over the skin since one year.

Histoid leprosy is a skin condition, a rare form of multibacillary leprosy. There was history of low-grade fever for 15 days, associated with redness, pain and discharge from eye, and nasal stuffiness. This case highlights the importance of FNAC in all similar cases where spindle cell nodular lesions of the skin are encountered. Arch Argent Dermatol ; Each of them can be hisroid from the histoid leprosy ihstoid the basis of its characteristic histopathology, the absence of lepra bacilli on slit skin smear and nerve thickening.

It was first described by Wade in in patients from Phillipines.

Lepromatous leprosy of histoid type Annigeri S R, Metgud S C, Patil J R – Indian J Med Microbiol

These cases may act as reservoirs of the disease and lead to further spread of leprosy. Leprosy relapse presenting in histoid form after MDT. A nine-year clinico-epidemiological study of histoid Hansen in India. It is considered by some as a variant of lepromatous leprosy and by others as a distinct clinical entity.


Nerve thickening and lymph node enlargement leprossy absent. The third pattern is most commonly observed [ 8 ]. These nodules often have central liquefaction necrosis with massive bacillary proliferation and neutrophilic infiltrations, characteristic of local exacerbation reaction [ 10 ].

The enormous bacillary population in histoid lesions is suggested to be due to focal loss of immunity [ 4 ]. Histopathology of the lower back nodule showed atrophic epidermis with a subepidermal grenz zone.

Pure fusocellular, fusocellular with epitheloid component and fusocellular with vacuolated cells. Lepr Rev ; Subscribe to Table of Contents Alerts.

Clinically it is characterized by multiple discrete shiny, smooth, painless, succulent, globular, protuberant, firm, skin colored to yellow brown, cutaneous, and, or subcutaneous nodules, papules, and plaques, on apparently normal skin.

Am J Trop Med Hyg. Continual occurrence of these cases does not bode well for eradication of leprosy. The impact of the entity on the leprosu leprosy elimination era. This article has been cited by other articles in PMC.

These histiocytes resemble fibroblasts and it is suggested that fibroblast-like macrophages may have arisen from the tissue histiocytes rather than blood monocytes. Multiple grouped shiny nodules over bony prominences. Closer view of Figure 1 Click here to view.

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